The role of non-coding RNAs in the management of neuropathic pain

Neuropathic pain is a chronic and debilitating condition that affects approximately 10% of the population in both the United States and Europe. Despite advances in understanding the mechanisms of neuropathic pain, current therapeutic options remain largely ineffective for a significant proportion of patients. Increasing evidence highlights the critical role of non-coding RNAs in regulating the expression of genes associated with neuropathic pain. Dysregulation of lncRNAs is now recognized as a key contributor to nociceptive hypersensitivity in neuropathic conditions. Understanding the molecular mechanisms behind these dysregulations offers promising opportunities for the development of new therapeutic strategies to prevent or alleviate neuropathic pain.

the role of non-coding RNAs in neuropathic pain. It is questionable whether modulation of these RNAs can produce targeted pain relief. This topic aims to elucidate the potential of non-coding RNAs for the development of personalized treatments for neuropathic pain by reviewing recent studies, including transcriptomic data and therapeutic implications. We invite submissions that provide novel insights into RNA-based therapeutics, RNA-pain interactions, and novel biomarkers for the management of neuropathic pain.

This research topic seeks contributions examining the roles of non-coding RNAs in the regulation and treatment of neuropathic pain. We invite studies on how altered non-coding RNA expression affects pain signaling, neuronal plasticity and inflammation in neuropathic contexts. Submissions investigating the therapeutic implications of targeting non-coding RNA, including RNA therapies, gene editing and modulation, are strongly encouraged.

We accept different types of manuscripts such as original research, reviews, mini-reviews, clinical trials and perspectives. Research on biomarker development, mechanistic insights and transcriptomic analyzes are particularly welcome. Authors are encouraged to present innovative research that improves understanding of the potential of non-coding RNAs in neuropathic pain management and treatment efficacy.

Key words: Non-coding RNAs, pain mechanisms, pain management, inflammation, neuroglia, cytokines, chemokines

Important note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to refer an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.

Neuropathic pain is a chronic and debilitating condition that affects approximately 10% of the population in both the United States and Europe. Despite advances in understanding the mechanisms of neuropathic pain, current therapeutic options remain largely ineffective for a significant proportion of patients. Increasing evidence highlights the critical role of non-coding RNAs in regulating the expression of genes associated with neuropathic pain. Dysregulation of lncRNAs is now recognized as a key contributor to nociceptive hypersensitivity in neuropathic conditions. Understanding the molecular mechanisms behind these dysregulations offers promising opportunities for the development of new therapeutic strategies to prevent or alleviate neuropathic pain.

the role of non-coding RNAs in neuropathic pain. It is questionable whether modulation of these RNAs can produce targeted pain relief. This topic aims to elucidate the potential of non-coding RNAs for the development of personalized treatments for neuropathic pain by reviewing recent studies, including transcriptomic data and therapeutic implications. We invite submissions that provide novel insights into RNA-based therapeutics, RNA-pain interactions, and novel biomarkers for the management of neuropathic pain.

This research topic seeks contributions examining the roles of non-coding RNAs in the regulation and treatment of neuropathic pain. We invite studies on how altered non-coding RNA expression affects pain signaling, neuronal plasticity and inflammation in neuropathic contexts. Submissions investigating the therapeutic implications of targeting non-coding RNA, including RNA therapies, gene editing and modulation, are strongly encouraged.

We accept different types of manuscripts such as original research, reviews, mini-reviews, clinical trials and perspectives. Research on biomarker development, mechanistic insights and transcriptomic analyzes are particularly welcome. Authors are encouraged to present innovative research that improves understanding of the potential of non-coding RNAs in neuropathic pain management and treatment efficacy.

Key words: Non-coding RNAs, pain mechanisms, pain management, inflammation, neuroglia, cytokines, chemokines

Important note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to refer an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.